Bubble Up Biscuit Pizza Casserole

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Imagine all the comforting flavors of your favorite pepperoni pizza, baked into a bubbling, golden, cheesy casserole that’s irresistibly easy to make. That’s what Bubble Up Biscuit Pizza Casserole delivers. This family-friendly dish combines buttery biscuit dough with rich pizza sauce, melty mozzarella, and layers of pepperoni in a one-pan meal that’s ready to win dinner.

Whether you’re looking for a quick weeknight fix or a crowd-pleasing party dish, this casserole has your back. It’s a smart way to satisfy pizza cravings without rolling out dough or fussing with delivery. Plus, it reheats beautifully, making leftovers just as crave-worthy.

What Kind of Biscuit Dough Should I Use?

You’ll want to use refrigerated biscuit dough—the kind that pops out of a tube. Choose a classic buttery or flaky variety. The dough puffs up as it bakes, creating that signature “bubble-up” effect and a fluffy, pizza-crust-like base.

Ingredients for the Bubble Up Biscuit Pizza Casserole

• Refrigerated Biscuit Dough: The base that gives this dish its name, biscuit dough bakes up fluffy and golden.
• Pizza Sauce: Rich, tomatoey, and full of Italian herbs, it brings all the pizza flavor.
• Mozzarella Cheese: Essential for that gooey, melty, cheesy goodness in every bite.
• Pepperoni Slices: Classic pizza topping, salty and slightly spicy for bold flavor.
• Shredded Cheddar Cheese: Adds a deeper flavor contrast to mozzarella.
• Olive Oil: Lightly greasing the baking dish ensures the biscuits don’t stick.
• Chopped Fresh Parsley (optional): Adds a pop of freshness and color.

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How To Make the Bubble Up Biscuit Pizza Casserole

Step 1: Prep Your Baking Dish

Preheat your oven to 375°F (190°C). Lightly grease a 9×13 inch baking dish with olive oil or nonstick spray.

Step 2: Cut and Toss the Biscuits

Open the biscuit tube and cut each biscuit into quarters. Place the pieces in a large bowl.

Step 3: Sauce and Mix

Add the pizza sauce to the bowl with the biscuit pieces and toss until evenly coated.

Step 4: Assemble the Layers

Spread the sauced biscuit pieces into the baking dish. Top with mozzarella and cheddar cheeses, then layer on pepperoni slices.

Step 5: Bake Until Golden

Bake uncovered for 25–30 minutes, or until the biscuits have puffed and the cheese is bubbling and golden brown.

Step 6: Garnish and Serve

Sprinkle with fresh parsley before serving for an herby finish.

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Serving and Storing Bubble Up Biscuit Pizza Casserole

This casserole is best served hot right out of the oven, when the cheese is melted and the biscuits are fluffy. If you have leftovers, let the dish cool completely, then cover and refrigerate for up to 3 days. Reheat individual portions in the microwave or oven until warmed through.

What to Serve With Bubble Up Biscuit Pizza Casserole?

Garlic Butter Green Beans

Lightly sautéed green beans with garlic offer a crisp and savory side.

Caesar Salad

A classic salad with crunchy croutons and creamy dressing balances the richness of the casserole.

Roasted Parmesan Broccoli

Try this cheesy veggie side like in our Roasted Parmesan Green Beans for texture contrast.

Marinara Dipping Sauce

Great for extra sauce lovers who like to dip every bite.

Italian Pasta Salad

Cold pasta tossed with veggies and vinaigrette adds a zesty bite.

Sparkling Lemonade

A refreshing drink to cut through the richness.

Garlic Knots

For those who simply can’t get enough doughy goodness.

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Want More Casserole Ideas?

If you love this pizza-inspired twist, try some of these other cozy casseroles from the ChefAlchemy collection:

• Cheesy Hamburger Casserole for a hearty, beefy classic.
• Million Dollar Ravioli Casserole layered with creamy indulgence.
• Chicken Marsala Casserole for an elegant twist on comfort food.
• French Onion Casserole with caramelized flavor in every spoonful.
• Walking Taco Casserole that brings the fiesta to your table.

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Tried this one-pan wonder? Let me know how it turned out in the comments. Did you stick with classic pepperoni, or mix in sausage, mushrooms, or bell peppers?

Looking for even more family-style favorites? Visit ChefAlchemy on Pinterest for daily inspiration and comfort food recipes made easy.

Explore more easy weeknight dinners and feel-good food combos in our Casserole Recipes section!

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