Get ready to elevate your pasta nights with this fiery, creamy Cajun Beef Spaghetti in Three-Cheese Parmesan Sauce. Imagine tender spaghetti wrapped in a rich, velvety cheese sauce infused with the bold spice of Cajun seasoning, topped with juicy ground beef, and finished with a sprinkle of fresh parsley. This dish brings the comfort of homestyle pasta and the excitement of Cajun flavors together in one irresistible bite.

Perfect for when you want something cozy yet flavor-packed, this meal delivers restaurant-quality satisfaction straight from your skillet. It’s the kind of recipe that becomes a family favorite from the first forkful. Whether you’re cooking for a weeknight dinner or impressing guests at your next gathering, this dish checks every box—cheesy, hearty, and incredibly crave-worthy.

What Kind of Cheese Should I Use for the Sauce?

For maximum depth and creaminess, a trio of cheeses does the trick: Parmesan for sharpness, mozzarella for stretch, and cream cheese for silky smoothness. They melt beautifully into the sauce, binding the Cajun spices and beef together into a luscious coating for the spaghetti. Make sure you use freshly grated Parmesan—it melts far better than the pre-shredded kind.

Ingredients for the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Ground Beef
Lean ground beef adds savory depth and meaty richness. Choose 80/20 for balance between flavor and fat.

Spaghetti Noodles
Classic spaghetti holds the sauce perfectly. Cook until al dente to avoid mushiness when tossed in the sauce.

Parmesan Cheese
Adds sharp, nutty flavor and boosts the umami of the sauce. Freshly grated is key.

Mozzarella Cheese
Provides that dreamy, stretchy cheese pull everyone loves.

Cream Cheese
Softens the spice and adds silky body to the sauce.

Heavy Cream
Creates a luxurious, creamy base that carries the cheese and spice beautifully.

Cajun Seasoning
Delivers bold Southern spice with a smoky kick. Use a store-bought blend or make your own.

Garlic & Onion Powder
Build foundational flavor that supports the beef and cheese.

Fresh Parsley
Brings freshness and a pop of color to finish.

Butter & Olive Oil
Used for sautéing beef and enhancing the sauce richness.

How To Make the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Step 1: Cook the Spaghetti

Boil a large pot of salted water and cook spaghetti according to package instructions until al dente. Drain and set aside, reserving 1/2 cup of the pasta water.

Step 2: Brown the Beef

In a large skillet, heat olive oil and butter over medium-high heat. Add the ground beef and season with Cajun seasoning, garlic powder, and onion powder. Sauté until fully browned and slightly crispy on the edges. Remove and set aside.

Step 3: Make the Cheese Sauce

Lower the heat to medium and in the same skillet, add heavy cream and cream cheese. Stir continuously until the cream cheese melts and blends smoothly. Gradually stir in shredded mozzarella and Parmesan. Let it simmer until thick and creamy. If it’s too thick, add a bit of reserved pasta water.

Step 4: Combine and Toss

Return the cooked spaghetti and browned beef to the skillet. Toss everything together until the noodles are fully coated in the cheese sauce and the beef is evenly distributed. Simmer for a couple of minutes to let all the flavors meld.

Step 5: Garnish and Serve

Turn off the heat and sprinkle freshly chopped parsley over the top. Serve hot, ideally in a warmed bowl to keep it creamy. Add extra Parmesan or a pinch of Cajun seasoning on top if you love more heat.

How to Serve and Store Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

When it comes to serving, this pasta is best enjoyed hot and fresh from the skillet. For presentation, garnish generously with fresh parsley and a final dusting of Parmesan. If you’re serving guests, try plating it in shallow pasta bowls to let the cheese sauce pool gently around the edges—restaurant-style elegance at home.

Leftovers? You’re in luck. Store any extras in an airtight container in the fridge for up to 4 days. Reheat gently in a saucepan over low heat with a splash of cream or milk to bring back the luscious texture. Avoid microwaving on high—low and slow keeps the sauce from breaking.

What to Serve With Cajun Beef Spaghetti?

Garlic Bread with Herb Butter

Perfect for mopping up every bit of that creamy cheese sauce.

Caesar Salad

The crisp lettuce and tangy dressing offer a fresh contrast to the richness of the pasta.

Roasted Broccoli or Asparagus

Roasted greens bring a slightly charred, earthy flavor that balances the dish.

Cornbread Muffins

Their slight sweetness is a delightful match to the spicy Cajun kick.

Baked Parmesan Zucchini Chips

A low-carb, crispy side that still feels indulgent.

Creamy Coleslaw

Adds a cool, crunchy counterpoint.

Sparkling Lemonade or Sweet Iced Tea

A refreshing drink helps tame the heat and complements the bold Cajun profile.

Want More Pasta Ideas with a Southern Twist?

If you’re loving this Cajun Beef Spaghetti, we’ve got more creamy, cheesy, and spicy recipes you’ll want to try next:

Try the Creamy Beef and Shells Recipe for another rich, beefy pasta experience.
Warm up with our comforting Stovetop Creamy Ground Beef Pasta — quick and loaded with flavor.
Dig into the Creamy Ground Beef Alfredo Pasta for a blend of familiar comfort and creamy indulgence.
The Cheesesteak Tortellini in Rich Provolone Sauce adds Philly flair to your pasta night.
Or go full fusion with Ultimate Cheesy Chicken Spaghetti — a creamy, spicy twist on classic spaghetti.

Save This Pin For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun? Swap in sausage instead of beef? Maybe added mushrooms or bell peppers?

I love seeing how you make these dishes your own. Questions welcome too—let’s make dinner magic together.

Explore beautifully curated health-boosting and indulgent pasta recipes on ChefAlchemy Recipes on Pinterest and find your next comfort food craving!