Spice meets comfort in this deliciously bold Cajun Garlic Butter Chicken with Creamy Parmesan Twisted Pasta. It’s the kind of dish that transforms your weeknight dinner into something you’d expect from a trendy bistro—rich, savory, and perfectly indulgent. The juicy chicken, seared with Cajun spices and bathed in a garlicky butter sauce, is the hero. Twisted pasta tossed in a creamy parmesan sauce finishes the plate with a luxurious touch.

This meal is fast enough for a busy evening but special enough for weekend company. The heat from the Cajun blend plays perfectly against the velvety cheese sauce, making it a flavor bomb in every bite. If you crave spicy comfort food with gourmet flair, this dish was made for you.

What Kind of Chicken Should I Use?

For the best results, boneless, skinless chicken breasts or thighs work beautifully. Breasts cook quickly and slice neatly, while thighs add an extra punch of flavor and juiciness. Either way, cut them into even pieces to ensure uniform cooking and maximum seasoning coverage.

Ingredients for the Cajun Garlic Butter Chicken with Creamy Parmesan Twisted Pasta

Chicken Breasts or Thighs — The protein star, perfect for soaking up the Cajun seasoning and garlic butter.

Cajun Seasoning — Brings heat and bold flavor; use store-bought or make your own with paprika, garlic powder, onion powder, cayenne, and herbs.

Butter — Essential for richness in both the garlic sauce and the pasta base.

Garlic — Freshly minced garlic infuses every bite with savory depth.

Heavy Cream — Creates the luxurious base of the parmesan pasta sauce.

Parmesan Cheese — Adds sharp, salty flavor to the creamy sauce. Use fresh-grated for the best melt.

Twisted Pasta (like fusilli or rotini) — The spiral shape holds onto the sauce, delivering flavor in every twirl.

Salt & Pepper — To enhance and balance the flavors throughout.

Olive Oil — Helps sear the chicken to a golden finish and lock in moisture.

How To Make the Cajun Garlic Butter Chicken with Creamy Parmesan Twisted Pasta

Step 1: Season and Sear the Chicken

Generously coat the chicken pieces in Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat and sear the chicken until golden brown and cooked through. Remove and set aside.

Step 2: Create the Garlic Butter Base

In the same skillet, reduce the heat to medium and add butter. Once melted, stir in minced garlic and cook until fragrant, about 1 minute.

Step 3: Cook the Pasta

Boil the twisted pasta according to package instructions until al dente. Reserve some pasta water before draining.

Step 4: Make the Creamy Parmesan Sauce

To the garlic butter, pour in the heavy cream and bring to a gentle simmer. Stir in freshly grated parmesan cheese and whisk until melted into a smooth sauce. Use reserved pasta water to thin if needed.

Step 5: Combine Chicken and Pasta

Return the seared chicken to the skillet. Add the cooked pasta and toss to coat everything in the creamy sauce. Let it simmer for another 2–3 minutes to allow the flavors to meld.

Step 6: Serve

Plate up a generous serving of pasta and top with extra grated parmesan or fresh herbs if desired.

How to Serve and Store This Cajun Pasta Dish

Serve the Cajun Garlic Butter Chicken with Creamy Parmesan Twisted Pasta hot, straight from the skillet. Garnish with a little extra parmesan or chopped parsley for freshness. This dish pairs beautifully with a crisp green salad or a warm slice of crusty garlic bread.

To store leftovers, transfer to an airtight container and refrigerate for up to 3 days. Reheat gently on the stovetop or in the microwave, adding a splash of cream or milk to keep the sauce velvety.

What to Serve With Cajun Garlic Butter Chicken Pasta?

Roasted Parmesan Green Beans

Their crispiness complements the creamy pasta while echoing the parmesan theme.

Cheesy Garlic Bread

Because there’s no such thing as too much garlic and cheese.

Simple Garden Salad

Fresh greens with a light vinaigrette help balance the richness of the dish.

Lemon-Garlic Roasted Broccoli

Adds a citrusy, healthy crunch that contrasts beautifully with the creamy sauce.

Creamy Tomato Basil Soup

A warm and tangy starter that plays well with Cajun spice.

Cornbread Muffins

Sweet and crumbly, they make an unexpected but welcome Southern-style side.

Pickled Red Onions or Jalapeños

Add brightness and a zippy punch that cuts through the richness.

Sparkling Lemon Water or Iced Tea

Cleanses the palate between spicy bites and adds refreshment.

Want More Chicken Pasta Ideas?

If this Cajun Garlic Butter Chicken with Creamy Parmesan Twisted Pasta has you hooked, you’ll definitely want to try these next:

Creamy Beef and Shells Recipe for a rich twist on a childhood classic.
Marry Me Chicken Pasta Recipe that’s as romantic as it is flavorful.
Stovetop Creamy Ground Beef Pasta when you’re craving hearty simplicity.
Cheesesteak Tortellini in Rich Provolone Sauce for cheese lovers who want a Philly twist.
Creamy Ground Beef Alfredo Pasta for a cozy, satisfying one-pot dinner.

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And let me know in the comments how yours turned out. Did you use chicken thighs or go with breasts? Did you add mushrooms, spinach, or a kick of chili?

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