Comfort food just got a flavor-packed upgrade with this Cheesy Garlic Twisted Pasta featuring Cajun-spiced ground beef and creamy Alfredo Velveeta sauce. It’s the ultimate one-pan pasta dinner for when you want something bold, cheesy, and incredibly satisfying. The twisted rotini noodles capture every drop of sauce, while the Cajun beef delivers smoky heat in every bite.

This is the kind of dish that keeps you coming back for seconds. Perfect for quick weeknight meals, game day spreads, or feeding a hungry crowd, it balances spice, creaminess, and that familiar cheesy comfort we all crave. Bonus: It’s all done in under 30 minutes!

What Kind of Pasta Should I Use?

Rotini (aka twisted pasta) is your best bet. Its ridges and spirals are sauce magnets, holding onto the cheesy Alfredo and seasoned ground beef in every forkful. Penne or fusilli make great substitutes, but skip smoother pasta shapes like spaghetti—they just don’t cling to the creamy Cajun goodness as well.

Ingredients for the Cheesy Garlic Twisted Pasta with Cajun Ground Beef and Alfredo Velveeta

Ground Beef
Hearty and protein-rich, this brings a savory base to the Cajun flavor.

Cajun Seasoning
Adds smoky, peppery heat to the beef. Make your own or use store-bought.

Garlic
Freshly minced garlic sautéed with beef for deep flavor.

Velveeta Cheese (Original or Queso Blanco)
Melted into Alfredo sauce for that smooth, melty texture.

Alfredo Sauce
Creates a rich, creamy backbone for the entire dish.

Rotini Pasta
Twisted pasta that traps sauce perfectly.

Butter
Used to sauté garlic and boost overall richness.

Parmesan Cheese
Grated on top for a sharp, salty finish.

Fresh Parsley (optional)
Adds color and freshness to balance the rich cheese.

Salt and Pepper
To taste—brings everything together.

How To Make the Cheesy Garlic Twisted Pasta with Cajun Ground Beef and Alfredo Velveeta

Step 1: Boil the Pasta

Cook rotini in salted water until al dente, according to package directions. Reserve 1/2 cup of pasta water, then drain.

Step 2: Brown the Beef

In a large skillet, heat a tablespoon of butter over medium heat. Add the ground beef and cook until browned, breaking it apart as it cooks. Drain excess grease.

Step 3: Add Garlic and Cajun Seasoning

Stir in minced garlic and Cajun seasoning. Cook for another 1–2 minutes until garlic is fragrant and the seasoning is fully absorbed into the beef.

Step 4: Build the Cheese Sauce

Reduce the heat to low. Stir in the Alfredo sauce and cubed Velveeta. Let it melt slowly, stirring often, until completely smooth and creamy.

Step 5: Combine with Pasta

Add the cooked rotini to the skillet. Toss until pasta is fully coated. If the sauce is too thick, add a splash of the reserved pasta water.

Step 6: Finish and Serve

Top with grated Parmesan and chopped fresh parsley if desired. Serve hot and cheesy!

How to Serve and Store This Pasta

Serve this dish piping hot, right off the stove. The sauce is creamiest when fresh and clings to the pasta perfectly. Top each serving with extra Parmesan and a sprinkle of parsley for that final touch of flavor and color.

Store leftovers in an airtight container in the fridge for up to 3 days. Reheat on the stovetop with a splash of milk or cream to loosen the sauce without breaking it. Microwaving works too, but stir halfway through for even heating.

It’s not ideal for freezing due to the cheese and cream, which can separate when thawed.

What to Serve With Cheesy Garlic Twisted Pasta

Garlic Breadsticks

Classic and perfect for scooping up cheesy sauce.

Cajun Roasted Veggies

Zucchini, bell peppers, or Brussels sprouts with Cajun spice echo the pasta’s flavors.

Crisp Side Salad

A refreshing counter to the creamy pasta. Try a romaine or arugula base with lemon vinaigrette.

Pickled Jalapeños

Add heat and tang that cut through the richness.

Sweet Cornbread

A touch of sweetness complements the spicy Cajun seasoning.

Iced Tea or Lemonade

Keeps the meal refreshing and casual.

Hot Sauce or Chili Oil

For guests who like to turn up the heat.

Want More Ground Beef & Creamy Pasta Ideas?

If the cheesy garlic twisted pasta hit the right notes, you’re going to love these comforting dishes:

Creamy Ground Beef Alfredo Pasta — indulgent, silky, and effortless for weeknight dinners
Cajun Beef Linguine in Creamy Velveeta Parmesan Garlic Sauce — smoky, rich, and cheesy perfection
Cheesy Rotini Pasta with Garlic Butter Sauce and Ground Beef — classic garlic butter meets hearty beef and pasta

Save This Pin For Later

📌 Pin this to your delicious dinner board so you can revisit when you crave melty, cozy pasta goodness.

Let me know—did you crank up the heat? Add extra cheese? I’d love to hear how you made it your own!

For even more recipe magic, visit ChefAlchemy Recipes on Pinterest and discover your next comfort food obsession.