Name: Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Cuisine: American
Ingredients: 2 chicken breasts; 1 tablespoon Cajun seasoning; 1 tablespoon olive oil; 8 ounces penne pasta; 1 cup heavy cream; 3 garlic cloves, minced; 1 cup Parmesan cheese, grated; 2 tablespoons butter; 2 tablespoons fresh parsley, chopped

If there ever was a dish that screamed comfort and bold flavor in one bite, it’s Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream. This irresistible combo of creamy pasta and spiced grilled chicken hits all the right notes for weeknight dinners or crowd-pleasing gatherings. With juicy, smoky chicken perfectly charred and resting on a bed of velvety penne, it’s a restaurant-worthy plate straight from your kitchen.

The beauty of this recipe is how it balances rich cheese sauce with the fiery edge of Cajun seasoning, rounded off by a hint of garlic and fresh parsley. Whether you’re serving it for a weekend indulgence or treating your family to something special midweek, it’s a dish that feels like a warm, cheesy hug with every forkful.

What Kind of Cajun Seasoning Works Best?

For the perfect blend of heat and depth, opt for a Cajun seasoning that has a good mix of paprika, garlic powder, onion powder, cayenne, and herbs. Homemade blends allow you to control the spice level, but if you’re going store-bought, choose one without too much salt so the flavor of the chicken really shines through. Brands like Slap Ya Mama or Tony Chachere’s are crowd favorites in the U.S.

Ingredients for the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Chicken Breasts – These are the star of the show. Thinly sliced for quicker grilling and better spice coverage.

Cajun Seasoning – Brings the heat, flavor, and a beautiful crust when grilled.

Olive Oil – Helps bind the spices to the chicken and encourages caramelization on the grill.

Penne Pasta – Its ridged surface holds onto all the luscious sauce.

Heavy Cream – The base of the garlic Parmesan sauce that gives this dish its richness.

Garlic – Fresh minced garlic infuses the sauce with deep flavor.

Parmesan Cheese – Freshly grated is best. It melts better and adds sharp, nutty undertones.

Butter – Adds smoothness and enhances the garlic notes in the sauce.

Parsley – Fresh and chopped, it brightens the final dish and adds a pop of color.

How To Make the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Step 1: Season and Marinate the Chicken

Place your sliced chicken breasts in a bowl, drizzle with olive oil, and coat generously with Cajun seasoning. Let it marinate for at least 30 minutes to soak in all the flavors.

Step 2: Grill the Chicken

Heat a grill pan or outdoor grill over medium-high heat. Grill the chicken for 4-5 minutes per side until fully cooked with nice charred lines. Set aside and keep warm.

Step 3: Cook the Penne

Bring a large pot of salted water to a boil. Cook the penne pasta according to the package directions until al dente. Drain and set aside.

Step 4: Make the Garlic Parmesan Sauce

In a large skillet, melt butter over medium heat. Add minced garlic and sauté for about a minute until fragrant. Pour in the heavy cream, stir gently, and bring to a simmer. Gradually whisk in the Parmesan cheese until melted and smooth.

Step 5: Combine Pasta with Sauce

Toss the cooked penne into the garlic Parmesan sauce, stirring until all pasta is coated evenly. Let it simmer for another 2 minutes to thicken slightly.

Step 6: Assemble and Serve

Plate the cheesy penne, top with slices of grilled Cajun chicken, and finish with chopped parsley. Optional: drizzle with extra sauce or a sprinkle of red pepper flakes for added kick.

How to Serve and Store This Cheesy Penne and Cajun Chicken

For the best experience, serve this dish immediately after assembling. The creamy sauce is at its silkiest and most flavorful right off the stove. Garnish with fresh parsley and an optional sprinkle of Parmesan for extra flair.

To store leftovers, transfer to an airtight container and refrigerate for up to 3 days. When reheating, add a splash of milk or cream to restore the sauce’s creamy texture. It reheats best on the stovetop over low heat.

What to Serve With Cheesy Penne and Cajun Chicken?

Garlic Bread

To soak up every drop of that savory sauce, a side of warm, buttery garlic bread is a must.

Caesar Salad

The crisp romaine and tangy dressing offer a refreshing contrast to the richness of the pasta.

Roasted Broccoli

Adds a smoky crunch and balances the dish with earthy greens.

Creamed Spinach

If you’re going full comfort food mode, this creamy side adds another layer of indulgence.

Balsamic Roasted Brussels Sprouts

The caramelized edges and tangy notes pair beautifully with the bold Cajun chicken.

Corn on the Cob

Sweet, juicy corn helps tame the heat of the Cajun seasoning.

Fried Zucchini Chips

Crispy and fun, these little bites make a great appetizer or side.

Caprese Salad

Fresh tomatoes and mozzarella drizzled with balsamic glaze bring a cooling contrast to the spice.

Want More Creamy Pasta Dinner Ideas?

If this cheesy Cajun chicken combo is up your alley, you’ll fall in love with these creamy favorites next:

Creamy Beef and Shells Recipe: Fast, filling, and perfect for leftovers.
Marry Me Chicken Pasta Recipe: A romantic classic that lives up to the name.
Stovetop Creamy Ground Beef Pasta: Rich and cozy with minimal cleanup.
Garlic Butter Chicken with Rigatoni and Parmesan: Garlicky heaven in every bite.
Creamy Garlic Chicken Breasts: Tender chicken smothered in a dreamy garlic cream sauce.

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And let me know in the comments how yours turned out! Did you go spicier with the Cajun? Did you add mushrooms or spinach? I’d love to hear your twists.

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