If you’re craving indulgent comfort food with a spicy twist, this Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is everything you need. Picture tender, blackened Cajun-seasoned chicken breast sliced over a bed of rich, creamy fettuccine tossed in a luscious garlic mozzarella sauce. It’s a full-on flavor explosion that balances bold spice with silky, cheesy richness.

This dish is made to impress—whether you’re whipping it up for a casual dinner or showing off at a weekend gathering. And the best part? It comes together in under an hour, making it a weeknight hero. Let the Cajun heat dance with that gooey cheese pull—every forkful is a celebration.

What Kind of Fettuccine Should I Use?

For this dish, classic fettuccine noodles work beautifully. They’re thick enough to hold the creamy cheese sauce and offer a satisfying bite that pairs well with hearty Cajun chicken. Fresh pasta is luxurious if you have it on hand, but dried fettuccine will hold up just as well, especially when cooked al dente.

Ingredients for the Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Cajun Chicken:

Boneless Skinless Chicken Breasts – They’re lean, cook quickly, and absorb Cajun spices well.
Cajun Seasoning – The heart of the flavor. A blend of paprika, garlic powder, onion powder, cayenne, and herbs gives the chicken its punch.
Olive Oil & Butter – For pan-searing the chicken to golden perfection with a rich, savory crust.

Fettuccine:

Fettuccine Pasta – Sturdy enough to carry the creamy sauce without getting soggy.

Garlic Mozzarella Cheese Sauce:

Garlic – Freshly minced for bold, aromatic flavor.
Heavy Cream – The base of our velvety sauce.
Mozzarella Cheese – For that melty, stretchy, cheesy dream.
Parmesan Cheese – Adds depth and sharpness.
Salt and Pepper – Simple but essential for balance.
Fresh Parsley – Brightens everything up with a pop of color and herbaceous finish.

How To Make the Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Step 1: Season and Cook the Chicken

Rub your chicken breasts generously with Cajun seasoning. Heat olive oil and butter in a skillet over medium heat and sear the chicken for about 5-6 minutes per side, or until golden and cooked through. Set aside and let rest.

Step 2: Boil the Fettuccine

Bring a pot of salted water to a boil and cook fettuccine according to package instructions until al dente. Drain and set aside.

Step 3: Create the Cheese Sauce

In the same skillet used for the chicken, add minced garlic and cook until fragrant. Pour in the heavy cream, then stir in mozzarella and parmesan cheeses until melted and smooth. Add salt and pepper to taste.

Step 4: Toss the Pasta

Add the cooked fettuccine to the skillet with the cheese sauce. Toss well to coat each noodle. Thin with pasta water if needed.

Step 5: Assemble and Garnish

Slice the rested Cajun chicken and lay it over the creamy pasta. Sprinkle with fresh parsley and serve hot.

Serving and Storing Creamy Cajun Chicken Fettuccine

This pasta dish is best served fresh, while the sauce is ultra-creamy and the chicken is still juicy. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. When reheating, add a splash of milk or cream to revive the sauce’s silky texture.

Avoid freezing, as creamy sauces tend to separate and lose their luxurious consistency when thawed.

What to Serve With Creamy Cajun Chicken Fettuccine?

Garlic Bread

Perfect for soaking up every last bit of that cheesy sauce.

Caesar Salad

The cool, crisp crunch balances out the richness of the dish.

Roasted Broccoli

Adds a healthy touch and a slight char that complements Cajun spices.

Grilled Asparagus

Elegant, flavorful, and lightly bitter to contrast the creamy pasta.

Tomato Cucumber Salad

Bright and refreshing with a bit of acidity.

Crispy Brussels Sprouts

For a nutty, crunchy side dish with texture.

Corn on the Cob with Butter

Sweet, juicy, and simply delightful alongside the heat of Cajun spice.

Iced Sweet Tea or Lemonade

To cool things down and keep the flavors balanced.

Want More Chicken Pasta Ideas?

If you’re loving this bold and creamy combo, check out these similar pasta sensations:

Ultimate Cajun Mozzarella Chicken Ranch Pasta – A Cajun-inspired favorite with creamy ranch notes.
Creamy Garlic Chicken Breasts – For those who want even more garlicky goodness.
Smoky Garlic Butter Chicken Pasta – A smoky twist on a creamy classic.
Creamy Beef and Shells Recipe – A different protein, same creamy satisfaction.
One Skillet Creamy Smoky BBQ Chicken Sausage Pasta – Perfect for smoky BBQ fans.

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And let me know in the comments how yours turned out. Did you double the cheese or tone down the Cajun heat? Did you sneak in spinach or mushrooms?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook with flair.

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