If you’re craving bold flavor, creamy comfort, and a kick of heat, this Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce might just be your new favorite dinner. Perfectly seasoned Cajun chicken, crispy and tender, is layered over a bed of rich, garlicky rotini pasta tossed in a silky mozzarella Alfredo sauce. It hits all the right notes: spicy, creamy, cheesy, and comforting.

This dish is ideal for busy weeknights or casual dinner parties when you want to impress without overcomplicating things. Whether you’re a pasta lover, a spice seeker, or just someone who appreciates a creamy chicken dish done right, this meal is going to earn a regular spot on your menu.

What Kind of Rotini Should I Use?

You’ll want rotini that holds sauce well, so traditional wheat or bronze-cut rotini is ideal. The spirals trap the Alfredo sauce in every twist, making each bite extra creamy. Avoid overcooking, as you want it to stay firm enough to support the richness of the dish.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Chicken Breast: Boneless, skinless cuts are best for juicy slices that sear beautifully.
Rotini Pasta: Its twisted shape is perfect for capturing the creamy Alfredo.
Mozzarella Cheese: Adds gooey, melty texture to the Alfredo for a stretchy pull.
Heavy Cream: Forms the rich, velvety base of your Alfredo sauce.
Parmesan Cheese: For a sharp, salty edge to balance the creaminess.
Butter and Garlic: The essential base for any rich Alfredo sauce.
Cajun Seasoning: The spicy backbone of the chicken—a mix of paprika, cayenne, garlic powder, and herbs.
Parsley: Fresh parsley brightens up the final dish with color and a hint of freshness.
Olive Oil: Needed for searing the chicken to golden perfection.
Salt and Pepper: To bring all the flavors together.

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Season and Sear the Chicken

Pat your chicken breasts dry and rub generously with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat. Sear the chicken for 5–6 minutes on each side until golden and fully cooked. Set aside to rest, then slice into strips.

Step 2: Boil the Pasta

Cook the rotini in a large pot of salted boiling water according to the package instructions. Drain and set aside, reserving about 1/2 cup of the pasta water.

Step 3: Make the Mozzarella Alfredo Sauce

In the same skillet used for the chicken, melt butter over medium heat. Add minced garlic and cook until fragrant. Pour in the heavy cream and bring to a gentle simmer. Stir in the shredded mozzarella and Parmesan cheese. Let it melt down to a creamy consistency, adding a splash of reserved pasta water if needed.

Step 4: Combine Pasta and Sauce

Toss the cooked rotini directly into the sauce. Mix until every spiral is coated. Taste and adjust seasoning with salt and pepper.

Step 5: Assemble and Serve

Plate the creamy rotini and top with sliced Cajun chicken. Sprinkle with chopped parsley and serve immediately.

How to Serve and Store Creamy Cajun Chicken Rotini

This dish is best served fresh while the cheese is melty and the chicken still crisp on the edges. Garnish with extra parsley or even a squeeze of lemon for brightness.

To store, transfer leftovers to an airtight container. Refrigerate for up to 3 days. Reheat gently on the stovetop or microwave with a splash of cream or milk to bring back the saucy goodness.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

Crispy, buttery garlic bread is perfect for scooping up that extra Alfredo sauce.

Caesar Salad

A crisp Caesar salad offers a refreshing contrast to the richness of the pasta.

Roasted Broccoli

Adds some green to your plate while providing a lovely crunch.

Sauteed Spinach

Quick and easy, spinach complements the creamy base without overwhelming the dish.

Corn on the Cob

Sweet, juicy corn brings a summer-friendly side to this hearty meal.

Caprese Skewers

Fresh mozzarella, tomatoes, and basil balance the spice in the chicken.

Baked Zucchini Fries

A healthier crunchy side that works well with Cajun seasoning.

Iced Tea or Lemonade

A cooling beverage pairs beautifully with the heat of Cajun spices.

Want More Creamy Pasta Ideas?

If you love this Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce, check out these other delicious comfort meals:

Creamy Ground Beef Alfredo Pasta for a beefy spin on creamy pasta.
Stovetop Creamy Ground Beef Pasta that’s simple, savory, and satisfying.
Creamy Beef and Shells Recipe with melt-in-your-mouth goodness.
Ultimate Cajun Mozzarella Chicken Ranch Pasta if you crave more Cajun-style comfort.
One Pot Cheesy Mozzarella Cajun Steak Pasta Fest when you want to keep the Cajun love going.

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And let me know in the comments how yours turned out. Did you go extra spicy or mellow it down? Did you use rotini or try another pasta shape?

I love seeing your twists on this dish! Share your experience, ask questions, or drop tips—let’s help each other cook better every night.

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