When creamy Alfredo sauce meets bold Cajun spice, magic happens. This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is comfort food with flair—a luscious, cheesy pasta dinner wrapped in crispy chicken perfection. The rotini noodles catch every bit of sauce, while the Cajun-seasoned crust on the chicken adds irresistible texture and spice.

Perfect for weeknights when you want something hearty, or for impressing guests without breaking a sweat, this dish combines layers of flavor with familiar favorites. The mozzarella Alfredo brings in smooth, creamy balance, and when paired with that Cajun kick? It’s game over. Expect requests for seconds—and maybe thirds.

What Kind of Pasta Should I Use?

Twisted pasta, like rotini or fusilli, is a dream for thick sauces like mozzarella Alfredo. The curves and ridges trap sauce in all the right ways. You can substitute penne or farfalle, but nothing beats the twirl and texture of a good rotini for this creamy combo.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Chicken breasts – Boneless, skinless chicken breasts are ideal for pounding thin and coating with that crispy Cajun breading. They deliver protein and soak up seasoning beautifully.

Cajun seasoning – This blend adds the spice and smokiness that contrasts with the creamy sauce. You can use store-bought or homemade.

Breadcrumbs & Parmesan – Together, they create that golden, crispy crust that makes the chicken the star.

Rotini pasta – Twisted to perfection, this pasta clings to the sauce for every bite to burst with flavor.

Butter & garlic – The start of any good Alfredo, these give the sauce depth and savory aroma.

Heavy cream – The base of the Alfredo, giving the sauce its luxurious texture.

Mozzarella cheese – Melts into the sauce for gooey, cheesy richness.

Parsley – Adds a fresh pop of color and flavor to cut through the richness.

Olive oil – Essential for pan-frying the chicken to crisp perfection.

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Prepare the Chicken

Start by slicing your chicken breasts in half horizontally to create thinner cutlets. Season both sides generously with Cajun seasoning. Dredge them in a mixture of breadcrumbs and grated Parmesan cheese.

Step 2: Crisp It Up

Heat olive oil in a skillet over medium heat. Cook the breaded chicken cutlets for about 4-5 minutes on each side until golden and cooked through. Let them rest before slicing.

Step 3: Boil the Pasta

While the chicken cooks, bring a large pot of salted water to a boil. Cook your rotini according to package instructions until al dente. Drain and set aside.

Step 4: Make the Mozzarella Alfredo

In a large saucepan, melt butter and sauté minced garlic until fragrant. Stir in heavy cream and bring to a gentle simmer. Add shredded mozzarella a handful at a time, stirring until melted and smooth.

Step 5: Combine

Toss the cooked rotini into the Alfredo sauce, coating every spiral. Sprinkle in chopped parsley for freshness. Plate the creamy pasta and top with sliced Cajun chicken.

Serving and Storing Creamy Cajun Chicken Twisted Pasta

Serve this dish hot, right after combining the pasta and sauce, so you get that perfect creamy texture. Garnish with extra parsley or a sprinkle of Parmesan if you’re feeling fancy.

For storing, keep leftovers in an airtight container in the fridge for up to 3 days. Reheat gently on the stove or in the microwave with a splash of milk or cream to loosen the sauce.

What to Serve With Creamy Cajun Chicken Twisted Pasta?

Garlic Bread

That crispy edge and buttery flavor pair perfectly with the rich Alfredo sauce.

Caesar Salad

A crisp, chilled Caesar salad brings a nice contrast to the warm and creamy pasta.

Roasted Broccoli

Adds texture and cuts through the richness of the dish.

Southern-Style Green Beans

Infuse a little homestyle comfort into your Cajun dinner.

Parmesan Roasted Asparagus

Crispy, cheesy, and light—just what you need to round out the meal.

Fresh Tomato Basil Salad

Bright, juicy, and refreshing alongside the spiced chicken.

Cornbread Muffins

Add a touch of Southern charm and a hint of sweetness.

Want More Chicken Pasta Ideas?

If this spicy-creamy combo hits all the right notes, explore more comforting and creative pasta meals:

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And let me know in the comments how yours turned out. Did you go extra on the Cajun spice? Try a cheddar blend instead of mozzarella? I love hearing how you make these your own.

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