Sicilian Meatloaf

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A bold and hearty twist on a weeknight classic, this Sicilian Meatloaf is where comfort meets rich Italian flavor. Stuffed with savory layers of ham, provolone cheese, and baby spinach, it’s a deliciously meaty roll that slices beautifully to reveal a stunning spiral center. Whether you’re hosting Sunday dinner or prepping for a cozy meal at home, this meatloaf delivers big taste with little fuss.

Topped with robust marinara sauce and served alongside tender zucchini noodles or classic spaghetti, it brings the taste of the Mediterranean straight to your table. It’s a family-favorite kind of recipe—easy to make, fun to slice, and even better the next day.

What Kind of Ground Beef Should I Use?

Go for 85/15 ground beef for the perfect balance of moisture and structure. Too lean, and your meatloaf will dry out; too fatty, and it could fall apart. If you’re mixing proteins (like pork or veal), stick to a similar fat content. For an even firmer texture, you can mix in some ground pork.

Ingredients for the Sicilian Meatloaf

Ground Beef: The base of the meatloaf—choose quality beef with balanced fat content for tenderness.

Breadcrumbs: Helps bind the meat together and soak up excess juices for a cohesive loaf.

Eggs: Acts as a binder, holding all the ingredients in place.

Parmesan Cheese: Brings umami and salty richness that enhances the overall flavor.

Italian Seasoning & Garlic Powder: A simple spice duo that gives classic Sicilian vibes.

Salt & Black Pepper: Essential for balance and bringing out the best in each component.

Ham Slices: Adds savory depth and that traditional Sicilian meat roll layer.

Provolone Cheese: Melts beautifully into the center, creating that gooey, cheesy middle.

Baby Spinach: Adds freshness, color, and a nutritional bonus.

Marinara Sauce: The perfect topping to add moisture and rich tomato flavor.

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How To Make the Sicilian Meatloaf

Step 1: Prep Your Loaf Base

In a large bowl, mix ground beef, breadcrumbs, eggs, Parmesan cheese, seasonings, salt, and pepper until just combined. Don’t overmix, or it may turn tough.

Step 2: Layer the Fillings

On a parchment-lined baking sheet, flatten the meat mixture into a large rectangle (about 1/2 inch thick). Lay down ham slices, then provolone, followed by a handful of spinach.

Step 3: Roll It Up

Carefully roll the meat into a log, jelly-roll style, starting from the shorter edge. Use the parchment to help lift and guide the roll tightly.

Step 4: Seal and Shape

Pinch the seams and ends to seal the roll. Tuck them under slightly so the filling doesn’t escape during baking.

Step 5: Bake It

Transfer to a loaf pan or keep on the sheet pan. Bake at 375°F for about 45–50 minutes, or until internal temp hits 160°F. In the final 10 minutes, spoon marinara over the top.

Step 6: Rest and Slice

Let it rest 10 minutes before slicing to keep it juicy. Garnish with fresh parsley and extra Parmesan if desired.

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Serving and Storing Sicilian Meatloaf

Serve hot slices of this cheesy meatloaf with extra marinara and a side of pasta, zoodles, or roasted veggies. It holds its shape perfectly, making it a great candidate for leftovers or next-day lunch sandwiches.

To Store: Wrap leftovers tightly or store in an airtight container. Keeps in the fridge for up to 4 days.

To Freeze: Slice and freeze portions separately with wax paper in between for easy grab-and-reheat meals.

What to Serve With Sicilian Meatloaf?

Garlic Roasted Green Beans

Their crisp-tender bite and garlicky aroma pair beautifully with the boldness of the meatloaf.

Cheesy Polenta

Creamy, buttery, and perfect for sopping up that luscious marinara sauce.

Italian Chopped Salad

A fresh, crunchy counterpart with olives, cherry tomatoes, pepperoncini, and red wine vinaigrette.

Roasted Parmesan Potatoes

Golden, crispy edges and a fluffy interior make them an ideal sidekick.

Zucchini Noodles

A lighter, low-carb option that complements the richness of the meat.

Creamy Broccoli Cheddar Soup

Comfort layered on comfort—a great option for cozy winter nights.

Garlic Breadsticks

A crunchy, buttery addition that’s always a hit.

Grilled Asparagus with Lemon

Adds a bright, earthy contrast to the deep flavors of the meatloaf.

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Want More Meatloaf & Comfort Food Ideas?

If this Sicilian Meatloaf is your kind of comfort food, you’ll want to check out these other comforting and cheesy favorites:

• The Comfort Classic Parmesan Meatloaf for another hearty dinner centerpiece.
• Creamy Beef and Shells Recipe when you’re craving creamy pasta.
• Cheesesteak Tortellini in Rich Provolone Sauce for a Philly twist in pasta form.
• Stovetop Creamy Ground Beef Pasta for a quick weeknight win.
• Cheesy Hamburger Casserole when you want cozy and cheesy in one bite.

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And let me know in the comments how yours turned out! Did you use a spicy marinara? Add mushrooms or swap out the cheese?

I love seeing how you make these dishes your own. Questions welcome too—let’s inspire each other to keep cooking with heart.

Explore beautifully curated comfort meals and hearty bites on ChefAlchemy Recipes on Pinterest and find your next dinnertime obsession!

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