When bold Cajun flavor meets creamy Velveeta comfort, you get a pasta dish that’s downright irresistible. This Ultimate Creamy Velveeta Penne Pasta Recipe with Cajun Beef Alfredo Sauce isn’t just a mouthful to say—it’s a full-on flavor explosion. Perfect for cozy nights, easy dinners, or when you’re hosting friends, this recipe brings together cheesy indulgence with a subtle kick of heat.

With every bite, you get the richness of Alfredo, the smooth melt of Velveeta, and a savory Cajun beef twist that turns a classic into something unforgettable. The sauce hugs every ridge of penne, delivering a luxuriously creamy texture and that perfect spice that lingers just enough. Ready in under 30 minutes, it checks all the boxes for an easy dinner idea that doesn’t compromise on taste.

What Kind of Velveeta Should I Use?

For this recipe, classic Velveeta works perfectly. It melts smoothly, delivers consistent flavor, and enhances the creamy Alfredo base without overpowering the Cajun beef. If you want to lean into spice, Velveeta Jalapeño is a fun variation that complements the Cajun profile beautifully.

Ingredients for the Ultimate Creamy Velveeta Penne Pasta Recipe with Cajun Beef Alfredo Sauce

Velveeta Cheese
The key to the sauce’s ultra-creamy texture. It binds everything together with that signature cheesy melt.

Penne Pasta
Penne’s tubular shape traps the creamy sauce perfectly, ensuring every bite is packed with flavor.

Ground Beef
Seasoned with Cajun spices, it adds a bold, meaty layer that balances the richness of the cheese.

Heavy Cream
Forms the base of the Alfredo sauce, giving it that silky, luxurious texture.

Cajun Seasoning
The star of the spice show—adds heat, depth, and a smoky finish to the beef and sauce.

Parmesan Cheese
For an extra punch of flavor and a touch of saltiness that rounds out the creamy blend.

Garlic
Minced fresh garlic enhances the sauce with aromatic warmth.

Butter
Adds richness to the sauce while helping the garlic and beef infuse deeply into the cream.

How To Make the Ultimate Creamy Velveeta Penne Pasta Recipe with Cajun Beef Alfredo Sauce

Step 1: Boil the Pasta

Bring a large pot of salted water to a boil. Add penne pasta and cook according to package directions until al dente. Drain and set aside.

Step 2: Cook the Cajun Beef

In a large skillet over medium heat, melt 1 tablespoon of butter. Add minced garlic and sauté for about 30 seconds until fragrant. Add the ground beef and cook until browned, breaking it apart with a spoon. Sprinkle in the Cajun seasoning and stir to coat evenly.

Step 3: Build the Sauce

Reduce the heat to low. Pour in the heavy cream and stir to combine with the seasoned beef. Let it simmer for a minute or two, then add the Velveeta cheese (cubed) and stir until completely melted and the sauce is smooth.

Step 4: Add Parmesan & Combine

Stir in the Parmesan cheese to enhance the sauce’s flavor. Toss in the drained penne pasta and fold until the pasta is well coated and creamy.

Step 5: Serve & Garnish

Serve hot, topped with a sprinkle of fresh parsley or extra Parmesan if desired. A dash of Cajun seasoning on top adds a visual pop and extra kick.

How to Serve and Store Your Velveeta Penne Pasta

Serve this pasta immediately while it’s warm and creamy for the best flavor and texture. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop or microwave with a splash of cream or milk to bring back its saucy goodness.

Avoid freezing this dish, as the texture of the Velveeta sauce can become grainy upon thawing.

What to Serve With Velveeta Penne Pasta?

Garlic Bread

Perfect for scooping up every drop of sauce. Crunchy outside, soft inside—it’s a no-brainer.

Caesar Salad

A crisp Caesar salad balances out the richness of the pasta with its tangy dressing and crunch.

Roasted Broccoli

A lighter green side that adds a healthy crunch and subtle sweetness to your plate.

Creamy Coleslaw

The cool, creamy texture of coleslaw contrasts beautifully with the heat of the Cajun seasoning.

Fried Zucchini Sticks

Crispy and golden, they offer a satisfying sidekick that pairs well with pasta.

Cornbread Muffins

Soft and slightly sweet, they add Southern charm and soak up that sauce like magic.

Pickled Jalapeños

Add them on the side for those who love an extra hit of spice.

Grilled Asparagus

A clean, smoky veggie that doesn’t compete with the boldness of the pasta.

Want More Creamy Pasta Dinner Ideas?

If you’re into creamy, crave-worthy pasta dishes with a twist, these other recipes are calling your name:

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And let me know in the comments how yours turned out. Did you add mushrooms or hot sauce? Maybe a sprinkle of green onions on top? I love hearing how others make these recipes their own.

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