Lorenzo Devereaux
Imagine sinking your fork into layers of savory seasoned beef, creamy cheese, and tender tortillas baked to golden perfection. This Mexican Lasagna Layered Beef Casserole is everything you love about classic comfort food, with a spicy Tex-Mex twist that keeps you coming back for seconds.
Perfect for weeknight dinners, potlucks, or even meal prepping, this casserole is hearty, cheesy, and bursting with flavor. Whether you’re feeding a crowd or just craving something cozy, it’s a guaranteed hit for anyone who loves bold, delicious Mexican-inspired meals.
What Kind of Tortillas Work Best for Mexican Lasagna Layered Beef Casserole?
Flour tortillas are the most commonly used because they hold their shape and soak up all the savory sauce without becoming soggy. However, if you want an extra authentic flavor, corn tortillas are an excellent choice, giving a rustic and slightly chewy texture. Whichever you choose, lightly toasting them first helps prevent them from getting too soft in the casserole.
Ingredients for the Mexican Lasagna Layered Beef Casserole
- Ground Beef – The heart of the casserole, providing a rich, savory base.
- Taco Seasoning – Adds the signature Mexican flavor with a perfect blend of spices.
- Onion and Garlic – Essential for depth and aroma in the beef mixture.
- Tomato Sauce & Salsa – Creates a flavorful, slightly tangy sauce that keeps the layers moist.
- Flour or Corn Tortillas – The “lasagna noodles” that hold everything together.
- Cheddar & Monterey Jack Cheese – Melts into gooey, cheesy layers for maximum comfort.
- Sour Cream – Creamy tang that balances the bold flavors.
- Fresh Cilantro & Diced Tomatoes – For a fresh and colorful garnish.
How To Make the Mexican Lasagna Layered Beef Casserole
Step 1: Brown the Beef and Aromatics
In a large skillet over medium heat, cook the ground beef until it’s browned and crumbly. Add diced onion and minced garlic, stirring until fragrant. Drain any excess fat before moving to the next step.
Step 2: Season and Simmer
Sprinkle in taco seasoning and mix well. Pour in tomato sauce and salsa, then let the mixture simmer for about 5–7 minutes. This step allows the flavors to meld and thicken slightly.
Step 3: Prepare the Tortillas
Lightly toast the tortillas in a dry skillet for 30 seconds per side. This prevents them from becoming overly soggy once baked.
Step 4: Layer the Casserole
In a greased baking dish, spread a thin layer of the beef mixture first. Follow with a layer of tortillas, then sprinkle cheese. Repeat this process until all ingredients are used, finishing with a generous cheese layer on top.
Step 5: Bake to Perfection
Cover with foil and bake in a preheated oven at 375°F (190°C) for 20 minutes. Remove the foil and bake for another 10 minutes, or until the cheese is bubbly and golden.
Step 6: Garnish and Serve
Allow the casserole to rest for 5 minutes before cutting. Top with sour cream, fresh cilantro, and diced tomatoes for a pop of freshness.
Serving and Storing Mexican Lasagna Layered Beef Casserole
This casserole is best enjoyed hot, straight from the oven, with the cheese still bubbling. For a party or family dinner, serve it in the baking dish so everyone can help themselves. Leftovers can be stored in an airtight container in the refrigerator for up to 4 days or frozen for up to 2 months. To reheat, simply warm it in the oven at 350°F until heated through, or microwave individual slices.
What to Serve With Mexican Lasagna Layered Beef Casserole?
1. Mexican Rice
A classic side that complements the bold flavors of the casserole.
2. Guacamole and Tortilla Chips
Adds creaminess and crunch for a fun, interactive side.
3. Roasted Parmesan Green Beans
A lighter veggie option that balances the richness of the dish.
4. Creamy Broccoli Cheddar Soup
A comforting soup pairing for chilly nights.
5. Jalapeño Poppers
Spicy and cheesy, they’re a great appetizer before diving into the casserole.
6. Mexican Restaurant-Style Cheese Dip
Perfect for dipping tortilla chips or drizzling over your slice of casserole.
7. Fresh Garden Salad
A refreshing way to add crunch and balance to your meal.
8. Sweet Corn and Shrimp Chowder
A creamy, slightly sweet option that pairs surprisingly well with the savory beef layers.
Want More Casserole Ideas?
If you loved this Mexican Lasagna Layered Beef Casserole, you’ll want to try these other comforting, cheesy favorites:
- Cheesy Hamburger Casserole – A hearty classic for busy weeknights.
- Walking Taco Casserole – All the taco flavors you love in a fun, layered bake.
- Million Dollar Ravioli Casserole – Creamy, rich, and absolutely irresistible.
- Spaghetti Squash Casserole – A lighter take that’s still full of flavor.
- Mexican Tortilla Casserole – Another Tex-Mex favorite you can’t miss.
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Mexican Lasagna Layered Beef Casserole
Equipment
- Large Skillet
- Baking dish
Ingredients
- 450 g ground beef
- 1 packet taco seasoning
- 1 small onion, diced
- 2 cloves garlic, minced
- 1 cup tomato sauce
- 1 cup salsa
- 8 medium flour or corn tortillas
- 1.5 cups shredded cheddar cheese
- 1.5 cups shredded Monterey Jack cheese
- 0.5 cup sour cream
- 2 tablespoons fresh cilantro, chopped
- 0.5 cup diced tomatoes
Instructions
- Brown the beef and aromatics: In a large skillet, cook ground beef over medium heat until browned. Add diced onion and minced garlic, cooking until fragrant. Drain excess fat.
- Season and simmer: Stir in taco seasoning, tomato sauce, and salsa. Simmer for 5–7 minutes.
- Prepare the tortillas: Lightly toast tortillas in a dry skillet for 30 seconds per side.
- Layer the casserole: In a greased baking dish, layer beef mixture, tortillas, and cheese. Repeat, finishing with cheese on top.
- Bake to perfection: Cover with foil and bake at 375°F (190°C) for 20 minutes. Remove foil and bake another 10 minutes until cheese is bubbly and golden.
- Garnish and serve: Rest 5 minutes before slicing. Top with sour cream, cilantro, and diced tomatoes.